Isolation and structure elucidation of cyclohexanepentol, an anti-psychotic agent from Cissampelos owarensis (P. Beauv.) leaves

Background: In Nigeria, an estimated 20 – 30% of our population is believed to suffer from mental disorders. Cissampelos owariensis has been used in Southwest Nigerian traditional medicine treat illness.Objectives: This study evaluated the anti-psychotic potential crude extract, fractions, sub-fractions and isolated compound, using vivo vitro antipsychotic assays.Material Methods: Crude extract fractions leaves were investigated against ketamine induced hyper-locomotion stereotype behaviours mice. Extrapyramidal effect bioactive fraction was tested catalepsy model. D - amino acid oxidase assay test for property chromatographic compound. Percentage inhibition pooled compound measured at excitation emission wavelengths 355 460 nm, respectively. Characterization done Infrared Nuclear Magnetic Resonance spectroscopy. One-way ANOVA, followed by Dunnett’s posthoc α0.05, data analysis.Results: (125 mg/kg) showed reduction different doses. The ethylacetate (500 significantly antagonized stereotypy ethyl acetate did not induce but rather reversed cataleptic haloperidol. Phytochemical investigation led identification Cyclohexanepentol, which possesses comparable activity with Risperidone.Conclusion: paper presents first time, principle C. validates its ethno-medicinal use.